Intestinal knowledge

《 Relationship between gut microbiota and disease》

More than 50 major chronic diseases are caused by the imbalance of the human intestinal flora. In 2018, world-renowned medical journals Sience, Nature and Cell published the relationship between enteric bacteria and various diseases. The latest research results recently announced include cancer, leukemia, diabetes, obesity, liver disease, arteriosclerosis, depression, autism, Parkinson's disease, ulcerative colitis, eczema, allergy, and more than 50 diseases. And chronic illnesses are listed as related to the balance of human gut microbiota.

Small intestine

The small intestine is not only an organ that digests and absorbs, but also has an immune function. The root cause of all illnesses is in the gut, which is the source of strength against various diseases and is the hottest research topic of the century. The intestines fully utilize and utilize their “guardian” intestinal bacteria and immune cells to control the body's immunity. Since about 70% of human immune cells are formed in the small intestine, it is important to pay attention to intestinal health after adulthood.

Enterobacteriaceae

Classification of enteric bacteria

 Mitsuoka Mitsuoka, President of the World Health Organization, Microbiological Society and Professor of the University of Tokyo, has divided enteric bacteria into three categories: good bacteria, bad bacteria, and opportunistic bacteria.

• ●When the fetus is in the mother's body, the intestines are sterile.
• ●Good bacteria account for about 95% at 3-5 days after birth.
• ●The number of bad bacteria increases from weaning to adulthood, and probiotics (Note 1) in the latter half of adulthood Decreased significantly. Conversely, bad bacteria increase dramatically.

• ●When you enter the old age, the good bacteria will decrease and become a genus of bad bacteria.
• ●The total number of bacteria in the intestine of an adult is constant, has not changed significantly throughout life, bad bacteria increase, Good bacteria tend to decrease.

The aging of the human body is proportional to the process by which good bacteria are decreasing. Older people are more likely to suffer from various chronic diseases, cancer, etc., all of which are rooted in the aging of the gut plexus, and immunity decreases. The figure is "decrease of good bacteria + increase of bad bacteria = increase of chronic diseases and cancer".

“Maintaining the superiority of good bacteria” means that the body is immune to illness, delays aging, and makes it difficult to get sick.

(Note 1) Probiotics is a group of living microorganisms that have a beneficial effect on humans.

Intestinal flora(Intestinal flora)

• ●Intestinal flora (also known as intestinal flora)

According to the latest research, there are more than 1000 types of bacteria in the intestine, more than 100 trillion bacteria, and its weight is about 1.5kg! It also becomes. Bacteria in the intestine are collected by type, and are planted densely on the wall of the intestine like a flower bed. It is called the intestinal flora (intestinal flora) and is also called the “gut flora” of immunity and health. This is why it is called the “second brain” and “the key to health”.

• ●The gut microbiota has a constant host and it is difficult to colonize foreign bacteria.

The intestinal flora is occupied by a certain number of hosts (the number of bacteria in the intestine does not change significantly in adults), among which good and bad bacteria compete intensely every day, and opportunistic bacteria determine their fighting situation. The number of bacteria in the intestine is constant, and as a result, one side increases and the other side decreases. is.

Good bacteria are mainly dependent on self-growth and can only be supplemented by oral administration afterwards, and it is difficult to become a host, so it is difficult to colonize the intestines. The balance of intestinal bacteria will collapse for various reasons such as age, environment and diet. As a result, when bad bacteria predominate, the balance of the intestinal environment is lost, and the health condition deteriorates.

According to the research result of Prof. Mitsuoka Mitsuoka, in order to maintain health in adults, the condition of good bacteria 20% and opportunistic bacteria 70% is kept, and bad bacteria must not exceed 10%.

Immune cells

• ●70% of the body's immune cells are in the small intestine.
• ●According to the latest scientific research, 70% of the body's immune cells are found in the small intestine. Healthy people produce thousands to tens of thousands of cancer cells every day. Of the 60 trillion cells in the human body, unless cancer cells proliferate, they are completely negligible. In addition, immune cells (white blood cells) protect the cancer cells from growing. Immune cells (white blood cells) travel through all parts of the body, and when cancer cells are found, they disappear. However, if the activity of immune cells declines and the body's immunity becomes low, cancer cells survive, proliferate, spread to other cellular tissues, and eventually spread throughout the body.

Immune cell base camp ---- Peier plate (intestinal lymph node)

• ●The body's immune cells are distributed in the bone marrow, thymus, and lymph nodes, but 70% are contained in Peyer's patches of the small intestine. The Peyer's board (Note 1) is the home of immune cells and a training ground. Leukocytes are mainly immune cells, and M cells (Note 2) are also present in this part.M cells target and block viruses that enter the body, and T cells (Note 3) and NK cells (Note 4) I will kill you.

(Note 1) Peyer's patch: A group of 10 to 40 lymph nodes, often found in the appendix and ileum. It functions in intestinal immunity.

(Note 2) M cells: Cells scattered between the absorbing epithelial cells of the follicular crust epithelium that covers Peyer's patches. It is thought to be involved in gastrointestinal immunity.

(Note 3) T cell: A type of lymphocyte that originates from bone marrow stem cells and differentiates in the thymus.

(Note 4) MK cells: Natural killer cells are literally born killer who patrol the whole body and attack cancer cells and virus-infected cells as soon as they are found.

Immune cells need activation and training. How do you activate it?

Without foreign substances such as bacteria and viruses, the immune system will not start, nor will immunity improve. But we don't need to get foreign objects into the body. There is a special method of ingesting lactic acid bacteria called “composite microecologic products”.

The cell wall of the cell contains special components that activate immune cells, and this special formulation that can activate the immune switch reaches the small intestine directly and in large quantities. At this time, Peyer's M cells treat it as a foreign object. This triggers the immune system and activates many immune cells. Thereafter, harmful substances such as mutant cells in the body are removed through the blood circulation of the human body.